With the large-scale application of precision guided weapons, it has realized the transition from conventional ammunition cluster attack mode to guided munition precision strike mode, thus achieving the best combat cost performance. Its laser weapons are widely used in the military field to effectively combat laser weapons. Smoke screen bombs are favored by all countries due to their high cost-effective advantages. In this study, taking the smoke screen interferes with laser terminal guided projectiles as an example, the guidance principle of laser terminal guided projectiles, and the principle of smoke screen interference with laser terminal guided projectiles were studied. The shielding effect of the smoke screen on the laser seeker was introduced into the simulation process of external ballistic. Taking miss distance as an indicator, the jamming system simulation model was established, and the simulation research of smoke screen against laser terminal guided projectiles was realized. The research results show that the simulation system can provide the best jamming strategy for smoke screens against laser terminal guided projectiles, and can provide auxiliary decision-making for combat training and effectiveness evaluation of typical smoke munitions.