Abstract: Photonic crystal fibers own the properties of endless single-mode, adjustable mode area and controlled dispersion which make it particularly suitable to achieve supercontinuum spectrum generation. One necessary condition of supercontinuum spectrum generation is that the used media has high nonlinear coefficient. Chalcogenide glass pocesses the property of very high nonlinear, so using chalcogenide glass photonic crystal fiber to generate supercontinuum spectrum has attracted widespread attention. In this work, Ge23Sb12S65 chalcogenide glass was fabricated using melt-quenching method and measured to have high nonlinear refractive index. Chalcogenide glass photonic crystal fibers used for mid-IR supercontinuum spectrum generation was designed and studied with multi-polar method. By controlling the hole spacing and the aperture ratio d/, the dispersion, loss and mode area optimized. Finally, a flattened dispersion photonic crystal fiber in the range 2-4m was obtained, with =2m and d/=0.43.