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定量相位显微中分辨率增强技术综述

郜鹏,  温凯,  孙雪莹,  姚保利,  郑娟娟

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文章导航 > 红外与激光工程  > 2019 >  48(6): 603007-0603007(13)
郜鹏, 温凯, 孙雪莹, 姚保利, 郑娟娟. 定量相位显微中分辨率增强技术综述[J]. 红外与激光工程, 2019, 48(6): 603007-0603007(13). doi: 10.3788/IRLA201948.0603007
引用本文: 郜鹏, 温凯, 孙雪莹, 姚保利, 郑娟娟. 定量相位显微中分辨率增强技术综述[J]. 红外与激光工程, 2019, 48(6): 603007-0603007(13). doi: 10.3788/IRLA201948.0603007
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Gao Peng, Wen Kai, Sun Xueying, Yao Baoli, Zheng Juanjuan. Review of resolution enhancement technologies in quantitative phase microscopy[J]. Infrared and Laser Engineering, 2019, 48(6): 603007-0603007(13). doi: 10.3788/IRLA201948.0603007
Citation: Gao Peng, Wen Kai, Sun Xueying, Yao Baoli, Zheng Juanjuan. Review of resolution enhancement technologies in quantitative phase microscopy[J]. Infrared and Laser Engineering, 2019, 48(6): 603007-0603007(13). doi: 10.3788/IRLA201948.0603007
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定量相位显微中分辨率增强技术综述

doi: 10.3788/IRLA201948.0603007
  • 1.

    西安电子科技大学 物理与光电工程学院,陕西 西安 710171;

  • 2.

    中国科学院西安光学精密机械研究所 瞬态光学与光子技术国家重点实验室,陕西 西安 710119;

  • 3.

    陕西师范大学 物理学与信息技术学院,陕西 西安 710119

基金项目: 

国家自然科学基金（61605150，61475187，6140524）;国家“千人计划”基金;高等学校学科创新引智计划（B17035）

详细信息
    作者简介:

    郜鹏(1983-),男,教授,硕/博士生导师,主要从事相位显微及超分辨光学显微技术方面的研究。Email:peng.gao@xidian.edu.cn

    通讯作者: 温凯(1995-),男,硕士生,主要从事相位显微成像方面的研究。Email:thinker_wk@163.com

  • 中图分类号: O436.1

Review of resolution enhancement technologies in quantitative phase microscopy

  • 1.

    School of Physics and Optoelectronic Engineering,Xidian University,Xi'an 710171,China;

  • 2.

    State Key Laboratory of Transient Optics and Photonics,Xi'an Institute of Optics and Precision Mechanics,Chinese Academy of Sciences,Xi'an 710119,China;

  • 3.

    College of Physics and Information Technology,Shaanxi Normal University,Xi'an 710119,China

  • 摘要: 定量相位显微（Quantitative Phase Microscopy，QPM）将相位成像和光学显微技术相结合，为微观物体的三维形貌、透明物体的厚度/折射率分布提供了一种快速、无损、高分辨率测量手段。然而，传统QPM成像系统依然是一个衍射受限系统，高分辨率与大视场难以同时兼顾。因此，如何在保持大视场的前提下提高成像空间分辨率是QPM亟需解决的问题之一。近年来，国内外学者采用离轴照明、散斑照明、结构照明、以及亚像元技术形成合成数值孔径，实现了QPM的大视场、高分辨成像。文中对以上QPM的分辨率增强技术进行了综述，并对不同方法的优缺点进行了分析。
    Abstract: Quantitative Phase Microscopy (QPM), which combines phase imaging and optical microscopy, has been acting as a fast, non-destructive, and high-resolution methodology to measure the 3D morphology of reflective samples, as well as the inner structure or the refractive index of transparent samples. Similar to other diffraction-limited imaging systems, QPM suffers from the contradiction between spatial resolution and field of view (FOV). Therefore, how to achieve high spatial resolution in a large FOV has attracted a lot of attentions in the field of optical microscopy. In recent years, people utilized off-axis illumination, speckle illumination, structural illumination, and sub-pixel technology to synthesize a larger numerical aperture (SNA), and consequently enhanced the resolution of QPM. The resolution enhancement technologies of QPM were reviewed in this paper. The advantages and limitations of different methods were analyzed.
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出版历程
  • 收稿日期:  2019-04-05
  • 修回日期:  2019-06-15
  • 刊出日期:  2019-06-25

定量相位显微中分辨率增强技术综述

doi: 10.3788/IRLA201948.0603007
  • 1. 西安电子科技大学 物理与光电工程学院,陕西 西安 710171;
  • 2. 中国科学院西安光学精密机械研究所 瞬态光学与光子技术国家重点实验室,陕西 西安 710119;
  • 3. 陕西师范大学 物理学与信息技术学院,陕西 西安 710119
    • 作者简介:

    郜鹏(1983-),男,教授,硕/博士生导师,主要从事相位显微及超分辨光学显微技术方面的研究。Email:peng.gao@xidian.edu.cn

    通讯作者: 温凯(1995-),男,硕士生,主要从事相位显微成像方面的研究。Email:thinker_wk@163.com
  • 收稿日期: 2019-04-05
  • 修回日期: 2019-06-15
  • 刊出日期: 2019-06-25
基金项目:

国家自然科学基金（61605150，61475187，6140524）;国家“千人计划”基金;高等学校学科创新引智计划（B17035）

  • 中图分类号: O436.1

摘要: 定量相位显微（Quantitative Phase Microscopy，QPM）将相位成像和光学显微技术相结合，为微观物体的三维形貌、透明物体的厚度/折射率分布提供了一种快速、无损、高分辨率测量手段。然而，传统QPM成像系统依然是一个衍射受限系统，高分辨率与大视场难以同时兼顾。因此，如何在保持大视场的前提下提高成像空间分辨率是QPM亟需解决的问题之一。近年来，国内外学者采用离轴照明、散斑照明、结构照明、以及亚像元技术形成合成数值孔径，实现了QPM的大视场、高分辨成像。文中对以上QPM的分辨率增强技术进行了综述，并对不同方法的优缺点进行了分析。

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