From bench to market:commercialization of photoacoustic imaging

Yasha Saxena; Chulhong Kim; Yao Junjie

doi:10.3788/IRLA201746.1103001

Volume 46 Issue 11

Dec. 2017

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Yasha Saxena, Chulhong Kim, Yao Junjie. From bench to market:commercialization of photoacoustic imaging[J]. Infrared and Laser Engineering, 2017, 46(11): 1103001-1103001(14). doi: 10.3788/IRLA201746.1103001

Citation:

Yasha Saxena, Chulhong Kim, Yao Junjie. From bench to market:commercialization of photoacoustic imaging[J]. Infrared and Laser Engineering, 2017, 46(11): 1103001-1103001(14). doi: 10.3788/IRLA201746.1103001

From bench to market:commercialization of photoacoustic imaging

doi: 10.3788/IRLA201746.1103001

1.
Department of Biomedical Engineering,Duke University,Durham,USA;
2.
Departments of Creative IT Engineering and Electrical Engineering,Pohang University of Science and Technology(POSTECH),Pohang,Republic of Korea

More Information

Author Bio:
Yasha Saxena (1990-),女,硕士生,主要从事光声成像技术方面的研究。Email:yasha.saxena@duke.edu
Received Date: 2017-10-25
Rev Recd Date: 2017-12-11
Publish Date: 2017-11-25

Abstract

Photoacoustic imaging (PAI) or optoacoustic imaging, the modern application of an ancient physical discovery to biomedical imaging, is without doubt one of the most exciting imaging technologies that has drawn increasing attention from biomedical specialists. In PAI, the rich contrast of optical excitation is seamlessly combined with the high spatial resolution and large penetration depth of ultrasonic detection to produce clear images of optically scattering biological tissues. As a complementary imaging modality that surpasses the territory of traditional microscopic optical imaging, PAI has been explored for numerous biomedical studies, and hence enthusiastically embraced by researchers around the globe who have attested to its unique imaging capabilities, namely the deep penetration and functional sensitivity. Not surprisingly, as the market clearly sees the promise, the commercial production of PAI systems has grown apace with the technological advancements and clinical applications. The adoption of commercial PAI in research and clinical settings has however seen difficulties, majorly due to costs, regulatory blocks, and competition with mainstream technologies. Here, from a practical standpoint, a wide range of commercial PAI systems currently available in the market were introduced, their advantages and disadvantages were analyzed, and the design considerations for targeted applications were emphasized. The key technological, logistical, and clinical issues were also discussed that need to be solved to accelerate the technology translations. By doing so, it is hoped that a clearer picture of the future commercialization of PAI for clinicians, researchers, and industrial entrepreneurs will be presented.
- photoacoustic imaging,
- commercialization,
- oxygenation saturation of hemoglobin,
- tumor imaging,
- breast cancer imaging,
- endoscopy

References

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From bench to market:commercialization of photoacoustic imaging

1. Department of Biomedical Engineering,Duke University,Durham,USA;

2. Departments of Creative IT Engineering and Electrical Engineering,Pohang University of Science and Technology(POSTECH),Pohang,Republic of Korea

Author Bio:

Received Date: 2017-10-25

Rev Recd Date: 2017-12-11

Publish Date: 2017-11-25

Key words:

Abstract: Photoacoustic imaging (PAI) or optoacoustic imaging, the modern application of an ancient physical discovery to biomedical imaging, is without doubt one of the most exciting imaging technologies that has drawn increasing attention from biomedical specialists. In PAI, the rich contrast of optical excitation is seamlessly combined with the high spatial resolution and large penetration depth of ultrasonic detection to produce clear images of optically scattering biological tissues. As a complementary imaging modality that surpasses the territory of traditional microscopic optical imaging, PAI has been explored for numerous biomedical studies, and hence enthusiastically embraced by researchers around the globe who have attested to its unique imaging capabilities, namely the deep penetration and functional sensitivity. Not surprisingly, as the market clearly sees the promise, the commercial production of PAI systems has grown apace with the technological advancements and clinical applications. The adoption of commercial PAI in research and clinical settings has however seen difficulties, majorly due to costs, regulatory blocks, and competition with mainstream technologies. Here, from a practical standpoint, a wide range of commercial PAI systems currently available in the market were introduced, their advantages and disadvantages were analyzed, and the design considerations for targeted applications were emphasized. The key technological, logistical, and clinical issues were also discussed that need to be solved to accelerate the technology translations. By doing so, it is hoped that a clearer picture of the future commercialization of PAI for clinicians, researchers, and industrial entrepreneurs will be presented.

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Reference (83)

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[2]	Brody H. Medical imaging[J]. Nature, 2013. 502(7473):S81.
[3]	Cox B, Laufer J G, Arridge S R, et al. Quantitative spectroscopic photoacoustic imaging:a review[J]. Journal of Biomedical Optics, 2012, 17(6):061202.
[4]	Greneur C L, Sagot B. Biomedical photoacoustic imaging patent landscape[R]. New York:Knowmade Company, 2015.
[5]	Taruttis A, Ntziachristos V. Advances in real-time multispectral optoacoustic imaging and its applications[J]. Nature Photonics, 2015, 9(4):219-227.
[6]	Wang L H V, Hu S. Photoacoustic tomography:in vivo imaging from organelles to organs[J]. Science, 2012, 335(6075):1458-1462.
[7]	Yao J J, Wang L H V. Photoacoustic microscopy[J]. Laser Photonics Reviews, 2013, 7(5):758-778.
[8]	Zackrisson S, van de Ven S M W Y, Gambhir S S. Light in and sound out:emerging translational strategies for photoacoustic imaging[J]. Cancer Research, 2014, 74(4):979-1004.
[9]	Wang L H, Yao J J. A practical guide to photoacoustic tomography in the life sciences[J]. Nature Methods, 2016, 13(8):627-638.
[10]	Vengerov M. An optical-acoustic method of gas analysis[J]. Nature, 1946, 158(4001):28-29.
[11]	Michaels J E. Thermal impact-the mechanical response of solids to extreme electromagnetic radiation[J]. Planetary and Space Science, 1961, 7:427-433.
[12]	White R M. Generation of elastic waves by transient surface heating[J]. Journal of Applied Physics, 1963, 34(12):3559-3567.
[13]	Amar L, Bruna M, Velghe M, et al. On Detection of laser induced ultrasonic waves in human eye and elaboration of a theory on fundamental mechanism of vision[J]. Zeitschrift Fur Angewandte Mathematik Und Physik, 1965, 16(1):182-183.
[14]	Kreuzer L B. Ultralow gas concentration infrared absorption spectroscopy[J]. Journal of Applied Physics, 1971, 42(7):2934-2943.
[15]	Bowen T. Radiation-induced thermoacoustic soft-tissue imaging[J]. IEEE Transactions on Sonics and Ultrasonics, 1982, 29(3):197737.
[16]	Rosencwaig A, Gersho A. Theory of the photoacoustic effect with solids[J]. Journal of Applied Physics, 1976, 47(1):64-69.
[17]	Rosencwaig A. Photoacoustics and photoacoustic spectroscopy[M]. New York:Wiley, 1980.
[18]	Kruger R A, Liu P, Fang Y R, et al. Photoacoustic ultrasound(Paus)-reconstruction tomography[J]. Medical Physics, 1995, 22(10):1605-1609.
[19]	Kruger R A, Liu P Y. Photoacoustic ultrasound-pulse production and detection in 0.5-percent Liposyn[J]. Medical Physics, 1994, 21(7):1179-1184.
[20]	Kruger R A. Photoacoustic ultrasound[J]. Medical Physics, 1994, 21(1):127-131.
[21]	Oraevsky A A, Esenaliev R O, Jacques S L, et al. Lateral and z-axial resolution in laser optoacoustic imaging with ultrasonic transducers[C]//SPIE, 1995, 2389:198-208.
[22]	Esenaliev R O, Oraevsky A A, Jacques S L, et al. Laser optoacoustic tomography for medical diagnostics:experiments with biological tissues[C]//SPIE, 1996, 2676:10.1117/12, 238817.
[23]	Oraevsky A A, Jacques S L, Tittel F K. Determination of tissue optical properties by piezoelectric detection of laser-induced stress waves[C]//SPIE, 1993, 1882:86-101.
[24]	Waldner M J, Knieling F, Egger C, et al. Multispectral optoacoustic tomography in Crohn's disease:noninvasive imaging of disease activity[J]. Gastroenterology, 2016, 151(2):238-240.
[25]	Vionnet L, Tateau J, Schwarz M, et al. 24-MHz scanner for optoacoustic imaging of skin and burn. medical imaging[J]. IEEE Transactions on Medical Imaging, 2014, 33(2):535-545.
[26]	Tzoumas S, Antonio N, Nikolaos C, et al. Effects of multispectral excitation on the sensitivity of molecular optoacoustic imaging[J]. Journal of Biophotonics, 2015, 8(8):629-637.
[27]	Taruttis A, Morscher S, Burton N C, et al. Fast multispectral optoacoustic tomography (MSOT) for dynamic imaging of pharmacokinetics and biodistribution in multiple organs[J]. PLoS One, 2012, 7(1):e30491.
[28]	Stoffels I, Morscher S, Helfrich I, et al. Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging[J]. Science Translational Medicine, 2015, 7(317):317ra199.
[29]	Sela G, Lauri A, Deanben X L, et al. Functional optoacoustic neuro-tomography (FONT) for whole-brain monitoring of calcium indicators[J]. Quantitative Biology, 2015, arXiv:1501.02450.
[30]	Razansky D, Baeten J, Ntziachristos V. Sensitivity of molecular target detection by multispectral optoacoustic tomography (MSOT)[J]. Medical Physics, 2009, 36(3):939-945.
[31]	Petrova E V, Oraevsky A A, Ermilov S A. Red blood cell as a universal optoacoustic sensor for non-invasive temperature monitoring[J]. Applied Physics Letters, 2014, 105(9):094103.
[32]	Oraevsky A A, Jacques S L, Tittel F K, et al. Lateral and z-axial resolution in laser optoacoustic imaging with ultrasonic transducers in optical tomography, photon migration, and spectroscopy of tissue and model media:theory, human studies, and instrumentation[C]//SPIE, 1995.
[33]	Nikitin S M, Khokhlova T D, Pelivanov I M. Temperature dependence of the optoacoustic transformation efficiency in ex vivo tissues for application in monitoring thermal therapies[J]. Journal of Biomedical Optics, 2012, 17(6):061214.
[34]	Herzog E, Taruttis A, Beziere N, et al. Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography[J]. Radiology, 2012, 263(2):461-468.
[35]	Esenaliev R O, Oraevsky A A, Jacques S L, et al. Laser optoacoustic tomography for medical diagnostics:experiments with biological tissues. in biomedical sensing, imaging, and tracking technologies I[C]//SPIE, 1996, 2676:238817.
[36]	Deliolanis N C, Ale A, Morscher S, et al. Deep-tissue reporter-gene imaging with fluorescence and optoacoustic tomography:A performance overview[J]. Mol Imaging Biol, 2014, 16(5):652-660.
[37]	Dean-Ben X L, Razansky D. Adding fifth dimension to optoacoustic imaging:volumetric time-resolved spectrally enriched tomography[J]. Light-Science Applications, 2014, 3:e137.
[38]	Brecht H P, Su R, Fronheiser M, et al. Whole-body three-dimensional optoacoustic tomography system for small animals[J]. Journal of Biomedical Optics, 2009, 14(6):064007.
[39]	Bost W, Stracke F, Wei B E C, et al. High frequency optoacoustic microscopy[C]//IEEE Eng Med Biol Soc, 2009, 2009:5883-5886.
[40]	Wang X D, Pang Y, Ku G, et al. Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain[J]. Nature Biotechnology, 2003, 21(7):803-806.
[41]	Zhang H F, Maslov K, Stoica G, et al. Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging[J]. Nature Biotechnology, 2006, 24(7):848-851.
[42]	de la Zerda A, Lius Z, Bodapati S, et al. Carbon nanotubes as photoacoustic molecular imaging agents in living mice[J]. Nature Nanotechnology, 2008, 3(9):557-562.
[43]	Kim J W, Galanzha E I, Shashkov E V, et al. Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents[J]. Nature Nanotechnology, 2009, 4(10):688-694.
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From bench to market:commercialization of photoacoustic imaging

doi: 10.3788/IRLA201746.1103001

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通讯作者: 陈斌, bchen63@163.com

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