Volume 48 Issue 9
Oct.  2019
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Ji Yi. Visible light optical coherence tomography in biomedical imaging[J]. Infrared and Laser Engineering, 2019, 48(9): 902001-0902001(9). doi: 10.3788/IRLA201948.0902001
Citation: Ji Yi. Visible light optical coherence tomography in biomedical imaging[J]. Infrared and Laser Engineering, 2019, 48(9): 902001-0902001(9). doi: 10.3788/IRLA201948.0902001

Visible light optical coherence tomography in biomedical imaging

doi: 10.3788/IRLA201948.0902001
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  • Author Bio:

    Ji Yi(1983-), male, PhD. Dr. Yi's research is focused on novel optical techniques for early disease detection, and monitoring disease progression and prognosis. Among other inventions, he developed various imaging methods that enable non-invasive detection of nanoscale structural alterations in tissue and the local oxygen metabolism. His research is at the interface of biophotonics, physics, engineering, biology and medicine, that ultimately aims to improve the health care of general public. Email:jiyi@bu.edu

  • Received Date: 2019-07-11
  • Rev Recd Date: 2019-08-21
  • Publish Date: 2019-09-25
  • Optical coherence tomography (OCT) is a widely used optical imaging modality for three-dimensional structural and functional imaging. The prevalent OCT systems use an invisible light laser source beyond 800 nm and up to 1 500 nm to allow deep image penetration in biological tissues. Recently, visible light OCT (vis-OCT) using a short wavelength range between 400 nm to 700 nm has gained significant progress and attracted interest in its unique capability of high resolution imaging and spatially-resolved spectroscopy. In this article, we will briefly review the recent advance of vis-OCT imaging and its potential biomedical applications.
  • [1] Fercher A F, Drexler W, Hitzenberger C K, et al. Optical coherence tomography-principles and applications[J]. Rep Prog Phys, 2003, 66:239-303.
    [2] Huang D, Swanson E A, Lin C P, et al. Optical coherence tomography[J]. Science, 1991, 254:1178-1181.
    [3] Leitgeb R A, Werkmeister R M, Blatter C, et al. Doppler optical coherence tomography[J]. Prog Retin Eye Res, 2014, 41:26-43.
    [4] Drexler W, Fujimoto J G. Optical Coherence Tomography:Technology and Applications[M]. Berlin:Springer, 2008:621-651.
    [5] Srinivasan V J, Sakad?i? S, Gorczynska I, et al. Quantitative cerebral blood flow with optical coherence tomography[J]. Opt Express, 2010, 18:2477-2494.
    [6] Kashani A H, Chen C L, Gahm J K, et al. Optical coherence tomography angiography:A comprehensive review of current methods and clinical applications[J]. Progress in Retinal and Eye Research, 2017, 60:66-100.
    [7] Carlo T E, Romano A, Waheed N K, et al. A review of optical coherence tomography angiography (OCTA)[J]. International Journal of Retina and Vitreous, 2015, 1:5.
    [8] Baran U, Wang R K. Review of optical coherence tomography based angiography in neuroscience[J]. Neurophotonics, 2016, 3:010902.
    [9] Boer J F, Hitzenberger C K, Yasuno Y. Polarization sensitive optical coherence tomography 2013; a review[Invited] [J]. Biomed Opt Express, 2017, 8:1838-1873.
    [10] Baumann B. Polarization sensitive optical coherence tomography:A review of technology and applications[J]. Applied Sciences, 2017, 7:474.
    [11] Siddiqui M, Nam A S, Tozburun S, et al. High-speed optical coherence tomography by circular interferometric ranging[J]. Nature Photonics, 2018, 12:111-116.
    [12] Shu X, Beckmann L J, Zhang H F. Visible-light optical coherence tomography:a review[J]. Journal of Biomedical Optics, 2017, 22:121707.
    [13] Povazay B, Apolonski A A, Unterhuber A, et al. Visible light optical coherence tomography[C]//Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI, International Society for Optics and Photonics, 2002, 4619:90-94.
    [14] Yi J, Chen S, Shu X, et al. Human retinal imaging using visible-light optical coherence tomography guided by scanning laser ophthalmoscopy[J]. Biomed Opt Express, 2015, 6:3701-3713.
    [15] Kho A, Srinivasan V J. Compensating spatially dependent dispersion in visible light OCT[J]. Opt Lett, 2019, 44:775-778.
    [16] Zhang T, Kho A M, Srinivasan V J. Improving visible light OCT of the human retina with rapid spectral shaping and axial tracking[J]. Biomed Opt Express, 2019, 10:2918-2931.
    [17] Ju M J, Huang C, Wahl D J, et al. Visible light sensorless adaptive optics for retinal structure and fluorescence imaging[J]. Opt Lett, 2018, 43:5162-5165.
    [18] Coquoz S, Marchand P J, Bouwens A, et al. Label-free three-dimensional imaging of Caenorhabditis elegans with visible optical coherence microscopy[J]. PLOS ONE, 2017, 12:e0181676.
    [19] Marchand P J, Szlag D, Bouwens A, et al. In vivo high-resolution cortical imaging with extended-focus optical coherence microscopy in the visible-NIR wavelength range[J]. Journal of Biomedical Optics, 2018, 23:036012.
    [20] Merkle C W. Chong S P, Kho A M, et al. Visible light optical coherence microscopy of the brain with isotropic femtoliter resolution in vivo[J]. Opt Lett, 2018, 43:198-201.
    [21] Marchand P J, Bouwens A, Szlag D, et al. Visible spectrum extended-focus optical coherence microscopy for label-free sub-cellular tomography[J]. Biomed Opt Express, 2017, 8:3343-3359.
    [22] Pi S, Camino A, Wei X, et al. Rodent retinal circulation organization and oxygen metabolism revealed by visible-light optical coherence tomography[J]. Biomed Opt Express, 2018, 9:5851-5862.
    [23] Chen S, Yi J, Liu W, et al. Monte Carlo investigation of optical coherence tomography retinal oximetry[J]. IEEE Transactions on Biomedical Engineering, 2015, 62:2308-2315.
    [24] Yi J, Wei Q, Liu W, et al. Visible-light optical coherence tomography for retinal oximetry[J]. Opt Lett, 2013, 38:1796-1798.
    [25] Yi J, Backman V. Imaging a full set of optical scattering properties of biological tissue by inverse spectroscopic optical coherence tomography[J]. Opt Lett, 2012, 37:4443-4445.
    [26] Faber D J, Aalders M C G, Mik E G, et al. Oxygen saturation-dependent absorption and scattering of blood[J]. Phys Rev Lett, 2004, 93:028102.
    [27] Leitgeb R, Wojtkowski M, Kowalczyk A, et al. Spectral measurement of absorption by spectroscopic frequency-domain optical coherence tomography[J]. Opt Lett, 2000, 25:820-822.
    [28] Morgner U, Drexler W, Krtner F X, et al. Spectroscopic optical coherence tomography[J]. Opt Lett, 2000, 25:111-113.
    [29] Yi J, Li X. Estimation of oxygen saturation from erythrocytes by high-resolution spectroscopic optical coherence tomography[J]. Opt Lett, 2010, 35:2094-2096.
    [30] Robles F E, Chowdhury S, Wax A. Assessing hemoglobin concentration using spectroscopic optical coherence tomography for feasibility of tissue diagnostics[J]. Biomed Opt Express, 2010, 1:310-317.
    [31] Robles F E, Wilson C, Grant G, et al. Molecular imaging true-colour spectroscopic optical coherence tomography[J]. Nature Photonics, 2011, 5:744-747.
    [32] Yi J, Liu W, Chen S, et al. Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation[J]. Light:Science Applications, 2015, 4:e334.
    [33] Chong S P, Merkle C W, Leahy C, et al. Cerebral metabolic rate of oxygen (CMRO2) assessed by combined Doppler and spectroscopic OCT[J]. Biomed Opt Express, 2015, 6:3941-3951.
    [34] Yi J, Chen S, Backman V, et al. In vivo functional microangiography by visible-light optical coherence tomography[J]. Biomed Opt Express, 2014, 5:3603-3612.
    [35] Chen S, Yi J, Zhang H F. Measuring oxygen saturation in retinal and choroidal circulations in rats using visible light optical coherence tomography angiography[J]. Biomed Opt Express, 2015, 6:2840-2853.
    [36] Liu R, Song W, Backman V, et al. Quantitative quality-control metrics for in vivo oximetry in small vessels by visible light optical coherence tomography angiography[J]. Biomed Opt Express, 2019, 10:465-486.
    [37] Liu R, Winkelmann J A, Spicer G, et al. Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography[J]. Light:ScienceApplications, 2018, 7:1-13.
    [38] Liu W, Wang S, Soetikno B, et al. Increased retinal oxygen metabolism precedes microvascular alterations in type 1 diabetic mice[J]. Invest Ophthalmol Vis Sci, 2017, 58:981-989.
    [39] Inner retinal oxygen metabolism in the 50/10 oxygen-induced retinopathy model|Scientific Reports. https://www.nature.com/articles/srep16752.
    [40] Song W, Fu S, Song S, et al. Longitudinal detection of retinal alterations by visible and near-infrared optical coherence tomography in a dexamethasone-induced ocular hypertension mouse model[J]. Neurophotonics, 2019, 6:041103.
    [41] Pi S, Hormel T T, Wei X, et al. Monitoring retinal responses to acute intraocular pressure elevation in rats with visible light optical coherence tomography[J]. Neurophotonics, 2019, 6:041104.
    [42] Soetikno B T, Shu X, Liu Q, et al. Optical coherence tomography angiography of retinal vascular occlusions produced by imaging-guided laser photocoagulation[J].Biomed Opt Express, 2017, 8:3571-3582.
    [43] Chen S, Liu Q, Shu X, et al. Imaging hemodynamic response after ischemic stroke in mouse cortex using visible-light optical coherence tomography[J]. Biomed Opt Express, 2016, 7:3377-3389.
    [44] Chen S, Shu X, Nesper P L, et al. Retinal oximetry in humans using visible-light optical coherence tomography[Invited] [J]. Biomed Opt Express, 2017, 8:1415-1429.
    [45] Boustany N N, Boppart S A, Backman V. Microscopic imaging and spectroscopy with scattered light[J]. Annual Review of Biomedical Engineering, 2010, 12:285-314.
    [46] Barer R, Tkaczyk S. Refractive index of concentrated protein solutions[J]. Nature, 1954, 173:821-822.
    [47] Yi J, Radosevich A J, Rogers J D, et al. Can OCT be sensitive to nanoscale structural alterations in biological tissue[J]. Opt Express, 2013, 21:9043-9059.
    [48] Cherkezyan L, Capoglu I, Subramanian H, et al. Interferometric spectroscopy of scattered light can quantify the statistics of subdiffractional refractive-index fluctuations[J]. Phys Rev Lett, 2013, 111:033903.
    [49] Radosevich A J, Yi J, Rogers J D, et al. Structural length-scale sensitivities of reflectance measurements in continuous random media under the Born approximation[J]. Opt Lett, 2012, 37:5220-5222.
    [50] Hunter M, Backman V, Popescu G, et al. Tissue self-affinity and polarized light scattering in the born approximation:A new model for precancer detection[J]. Phys Rev Lett, 2006, 97:138102.
    [51] Terry N G, Zhu Y, Rinehart M T, et al. Detection of dysplasia in Barrett's ssophagus with in vivo depth-resolved nuclear morphology measurements[J]. Gastroenterology, 2011, 140:42-50.
    [52] Qiu L, Pleskow D K, Chuttani R, et al. Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett's esophagus[J]. Nature Medicine, 2010, 16:603-606.
    [53] Mirabal Y N, Chang S K, Atkinson E N, et al. Reflectance spectroscopy for in vivo detection of cervical precancer[J]. Journal of Biomedical Optics, 2002, 7:587-595.
    [54] Canpolat M, Akman-Karakas A, Gkhan-Ocak G A, et al. Diagnosis and demarcation of skin malignancy using elastic light single-scattering spectroscopy:A pilot study[J]. Dermatologic Surgery, 2012, 38:215-223.
    [55] Lichtenegger A, Harper J D, Augustin M, et al. Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer x02019; s disease brain samples[J]. Biomed Opt Express, 2017, 8:4007-4025.
    [56] Harper D J, Konegger T, Augustin M, et al. Hyperspectral optical coherence tomography for in vivo visualization of melanin in the retinal pigment epithelium[J]. J Biophotonics, 2019:e201900153.
    [57] Harper D J, Augustin M, Lichtenegger A, et al. White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina[J]. Biomed Opt Express, 2018, 9:2115-2129.
    [58] Zhang X, Hu J, Knighton R W, et al. Dual-band spectral-domain optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer[J]. Opt Express, 2011,19:19653-19659.
    [59] Chen S, Shu X, Yi J, et al. Dual-band optical coherence tomography using a single supercontinuum laser source[J]. Journal of Biomedical Optics, 2016, 21:066013.
    [60] Song W, Zhou L, Zhang S, et al. Fiber-based visible and near infrared optical coherence tomography (vnOCT) enables quantitative elastic light scattering spectroscopy in human retina[J]. Biomed Opt Express, 2018, 9:3464-3480.
    [61] Song W, Zhang L, Ness S, et al. Wavelength-dependent optical properties of melanosomes in retinal pigmented epithelium and their changes with melanin bleaching:a numerical study[J]. Biomed Opt Express, 2017, 8:3966-3980.
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Visible light optical coherence tomography in biomedical imaging

doi: 10.3788/IRLA201948.0902001
  • 1. Department of Medicine,Boston University School of Medicine,Boston Medical Center,Boston,MA 02118;
  • 2. Department of Biomedical Engineering,Boston University,Boston,MA 02215;
  • 3. Department of Electric and Computer Engineering,Boston University,Boston,MA 02215
  • Author Bio:

Abstract: Optical coherence tomography (OCT) is a widely used optical imaging modality for three-dimensional structural and functional imaging. The prevalent OCT systems use an invisible light laser source beyond 800 nm and up to 1 500 nm to allow deep image penetration in biological tissues. Recently, visible light OCT (vis-OCT) using a short wavelength range between 400 nm to 700 nm has gained significant progress and attracted interest in its unique capability of high resolution imaging and spatially-resolved spectroscopy. In this article, we will briefly review the recent advance of vis-OCT imaging and its potential biomedical applications.

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